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      Buy JWH-018. (1-pentyl-3-(1-naphthoyl)indole) or AM-678[1] is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human consumption”

JWH018.svg
JWH-018 ball-and-stick model.png
Clinical data
Routes of
administration
Smoked, Oral
Legal status
Legal status
  • AU: S9 (Prohibited)
  • CA: Schedule II
  • DE: Anlage II (Authorized trade only, not prescriptible)
  • US: Schedule I
Identifiers
CAS Number
  • 209414-07-3 
PubChem CID
  • 10382701
ChemSpider
  • 8558143 Yes
ChEMBL
  • CHEMBL561013 Yes
ECHA InfoCard 100.163.574
Chemical and physical data
Formula C24H23NO
Molar mass 341.45 g/mol
Solubility in water hydrophobic, n/a mg/mL (20 °C)
Yes (what is this?)  (verify)

    JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2.[3] JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors.[12] JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. Buy jwh-018 online and get discreet packaging 

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